A MISSISSIPPI BABY born with the AIDS virus and in remission for more than two years despite stopping treatment now shows signs that she still harbours HIV — and therefore is not cured.
The news is a setback to hopes that very early treatment with powerful HIV drugs might reverse an infection that has seemed permanent once it takes hold.
The girl is now nearly 4.
As recently as March, doctors had said that she seemed free of HIV though she was not being treated with AIDS drugs. That was a medical first.
But yesterday doctors said they were surprised last week to find the virus in her blood, and there were signs that it was harming her immune system. She is now back on treatment and is responding well, they said.
The news is “obviously disappointing” and will affect a federal study that had been about to start testing early, aggressive treatment in such cases, said Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases. Doctors had been considering stopping treatment if no signs of infection could be detected after two years.
“We’re going to take a good hard look at the study and see if it needs any modifications,” either in terms of length of treatment or because of ethical concerns over raising false hopes about an approach that now has suffered a setback, Fauci said. At a minimum, consent forms to join the study must be revised, he said.
Most HIV-infected moms in the U.S. get AIDS medicines during pregnancy, which greatly cuts the chances they will pass the virus to their babies. The Mississippi baby’s mom received no prenatal care and her HIV was discovered during labor. Because of the baby’s great risk of infection, doctors started her on unusually powerful treatment 30 hours after birth, even before tests could determine whether she was indeed infected.
The girl was treated until she was 18 months old, when doctors lost contact with her. Ten months later when she returned, they could find no sign of infection even though the mom had stopped giving her AIDS medicines.
Tests repeatedly showed no detectable HIV until last week, when copies of the virus were measured in her blood. Doctors say they don’t know why the virus rebounded when it did, and said it raises profound questions about what they know about HIV’s hideouts in the body.
Only one other person is thought to have been cured of HIV infection — a San Francisco man who had a bone marrow transplant in 2007 from a donor with natural resistance to HIV. He showed no sign of infection more than five years later.
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