A SIX-YEAR-OLD girl has been reported missing from her home in Tucson, Arizona in the US, sparking a huge search involving US marshals and the FBI.

According to the LA Times, first grader Isabel Mercedes Celis was last seen by her family in her bedroom at 11pm on Friday. When her parents went to wake her up the next morning at 8am, she was nowhere to be found.

Police were called by 8.14am and are still trying to ascertain if she was kidnapped or wandered off on her own. According to local news station KVOA, police have called the disappearance “suspicious”, adding that it could be a “possible abduction”.

Sgt. Maria Hawke with the Tucson Police Department said it was less likely the girl went anywhere on her own given that there was no sight of her 24 hours later.

Between 75 and 100 officers, air units, search and rescue experts, a rapid response team and bloodhounds have been deployed in the search. Detectives are also investigating if there are any signs of a break-in at the family’s home.

Isabel lives with her parents and two older brothers. As both parents live in the home, police have no indication that a child custody dispute is involved.

Friends of the family and local people have gathered to distribute fliers with a photo of Isabel.

-Additional reporting by AP