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Scientists are developing personalised cancer 'vaccines'

New research shows our bodies can be trained to fight certain kinds of tumours.

A NEW STUDY into how the body battles certain cancers has indicated that we can train our immune systems, or ‘vaccinate’ them in order to fight the disease more effectively.

The American study, published in the academic journal Science, performed tests on three people with varying levels of skin cancer.

Skin cancer tumours are basically highly-mutated versions of our genetic code, with no two exactly alike, each containing hundreds of random mutations unique to every patient.

The researchers involved, mainly based at Washington University in St. Louis, Missouri, analysed the skin tumours of the three subjects, looking to predict unique indicators that would be displayed by the cancer cells.

researchers Researchers preparing the vaccine Washington University Washington University

After data analysis a computer algorithm then predicted which areas of each tumour would be the best target for a vaccine.

Each of the three patients (who all had advanced tumours) was then given a personalised vaccine in 2013.

One is now cancer-free, another remains stable, while the third patient’s tumour shrank after the vaccine treatment before returning to its original size and remaining stable.

The research team now say their vaccine has been definitively proved to provoke a response from a patient’s immune system.

Gerald Linette Dr. Gerald Linette, leader of the clinical trial Siteman Cancer Centre Siteman Cancer Centre

“These custom-designed vaccines can elicit a very strong immune response,” said Dr. Gerald Linette, the specialist leading the trial.

Our results are preliminary, but we think the vaccines have therapeutic potential based on the breadth and remarkable diversity of the T-cell response.

“The trial shows that it may be possible to create vaccines that are tailored to the specific genetic mistakes in a patient’s cancer,” says Dr Alan Worsley, of Cancer Research UK.

At the moment it’s not clear how effective this would be at killing cancer cells in the body and improving survival, but it sets the stage for creating vaccines that are designed to target each patient’s individual tumour in the future.”

There are, as there always will be, certain drawbacks.

For starters, the vaccines that have been produced thus far take between three and four months to manufacture for each individual, although it is expected that can be reduced to a month or six weeks.

Before the vaccine can be produced en masse it will have to go through rigorous clinical trials.  And finally, the cost may well be prohibitive.

The positives outweigh the negatives however.

Given the nature of the tumours being treated, if successful the vaccines could eventually be used to effectively treat other highly-mutated cancers such as those found in the lung or bladder.

Read: Louise McSharry will be back on air this month

Read: Someone is diagnosed with cancer every 15 minutes in Ireland

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23 Comments
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    Mute Ranty McCrank
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    Dec 12th 2017, 7:04 PM

    You can be sure he’ll be a permanent citizen of this country in no time as per the Kalergi plan. He’d be ejected out of Poland or Hungary after a terrible prison stay but not in weak Western Europe controlled by Sutherland and Soros.

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    Mute BrianMcB
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    Dec 12th 2017, 7:26 PM

    @Ranty McCrank: Where are the open border champions now? He probably is one through his child thanks to meeting an Irish woman…

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    Mute Ranty McCrank
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    Dec 12th 2017, 7:31 PM
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    Mute billy Dorney
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    Dec 12th 2017, 10:40 PM

    @Ranty McCrank: we’re wussies

    21
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    Mute Danny Rafferty
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    Dec 13th 2017, 1:40 AM

    @BrianMcB: Explain your open-border point please?
    You’re alluding to something vaguely. What is the point you are making?
    Are you suggesting we shut down all inward migration?

    9
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    Mute Misanthrope
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    Dec 13th 2017, 2:32 AM

    @Danny Rafferty: how about controlling immigration. Rather than invite all and sundry without restriction why not vet immigrants for illness, criminality and skills and remove them within ,say 10yrs, if they commit a significant crime or is that racist xenophobia?

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    Mute Fiona deFreyne
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    Dec 12th 2017, 7:39 PM

    7 and a half years seems very lenient having regard to the nature and circumstances of this vicious and predatory crime. No contrition, no admission, and he sought to destroy their characters of the victims as part of his vicious defence.

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    Mute Deborah Behan
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    Dec 12th 2017, 10:38 PM

    @Fiona deFreyne: joke of a sentence.

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    Mute WJH
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    Dec 12th 2017, 6:55 PM

    Seven and a half years???? That’s just over 3 and a half years per woman he violated, drugged and raped. Enough said really about our justice system.

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    Mute Kal Ipers
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    Dec 12th 2017, 7:41 PM

    @WJH: Just want to point out there was no evidence of drugs. I am not denying what they said but there is only the suggestion of drugs. If there was evidence it would have been given. It sounds like they reported it quickly and would have run a blood test.

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    Mute Niall O Neill
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    Dec 12th 2017, 7:48 PM

    @WJH: don’t forget the concurrent element of the already laughable sentence…

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    Mute PDiddy
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    Dec 12th 2017, 8:21 PM

    @Kal Ipers: apparently the rape drug is nearly impossible to detect in tests.

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    Mute Robc
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    Dec 13th 2017, 2:02 AM

    @Kal Ipers: doesn’t matter whether drugs were involved. He was convicted of rape and sexual assault. He is filth, end of story.

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    Mute Kal Ipers
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    Dec 13th 2017, 7:53 AM

    @PDiddy: not true. Urban legend

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    Mute Dj
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    Dec 12th 2017, 7:06 PM

    Hopefully he’ll get battered in prison.

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    Mute Misanthrope
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    Dec 13th 2017, 2:34 AM

    @Dj: hopefully but it’s a sad reflection on us as a society when we’re hopeing other criminals deliver justice for us.

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    Mute Remy
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    Dec 12th 2017, 8:37 PM

    He should be fitted for a pair of cement shoes and shown how to swim in them.

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    Mute Caroline Otoole
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    Dec 12th 2017, 7:24 PM

    Too short, but at least no suspended element. Watch this space for many time wasting, legal aid funded actions brought by this delousional cad.

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    Mute Misanthrope
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    Dec 13th 2017, 2:35 AM

    @Caroline Otoole: The only suspended element of a sentence should involve a tree and a rope.

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    Mute Don Shavago
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    Dec 12th 2017, 6:56 PM

    No comments? Yet? Perhaps this will not be commented on due to his rich South Dublin heritage

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    Mute @aidoroch
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    Dec 12th 2017, 7:01 PM

    @Don Shavago: he’s from Cameroon

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    Mute Don Shavago
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    Dec 12th 2017, 7:02 PM

    @@aidoroch: That sounds a little racist IMHO

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    Mute Danielle Kenny
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    Dec 12th 2017, 7:07 PM

    @Don Shavago: does it not say in the article he’s originally from Cameroon and then lived in Sligo town? Are you acting thick on purpose or what?

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    Mute Tomek Olo Łęcki
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    Dec 12th 2017, 11:33 PM

    @Don Shavago: what sounds a little racist??? explain me please?? stop using words which you don’t understand

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    Mute Ray Farrell
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    Dec 12th 2017, 7:00 PM

    Should be strung up for his actions.

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    Mute Don Shavago
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    Dec 12th 2017, 7:02 PM

    @Ray Farrell: Ah, don’t be racist

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    Mute Tommy Roche
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    Dec 12th 2017, 7:07 PM

    @Ray Farrell: …by the nuts. With razor wire.

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    Mute Flip off
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    Dec 12th 2017, 7:57 PM

    Just a quick question Tommy. If you think he should be strung up by the nuts with razor wire as punishment, what would you think a suitable punishment for females who commit equally heinous crimes? given they lack nuts.

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    Mute Misanthrope
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    Dec 13th 2017, 2:36 AM

    @Flip off: a solution can be found to that minor mechanical issue

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    Mute Paul Mc Nulty
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    Dec 12th 2017, 11:08 PM

    7 years ? Shows how out of touch the judiciary are.

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    Mute paul smith
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    Dec 13th 2017, 7:32 AM

    when you have open borders you have to accept the good with the bad this guy should be banned from the country after his release but we know that wont happen, this is a heinous crime against these women

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    Mute Eóghan Ó Goirmghialla
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    Dec 14th 2017, 1:22 PM

    Cultural enrichment.

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