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A NEW APPROACH to killing cancer cells that uses a patient’s own immune system has beaten back leukaemia in 88 percent of adults, US researchers said today.
The report by scientists in New York offers more good news for the burgeoning field of cancer immunotherapy, which uses what some describe as a “living drug” that was hailed by Science magazine as the breakthrough of 2013.
Blood cancer
The latest trial, published in the journal Science Translational Medicine, involved 16 people with a kind of blood cancer known as adult B cell acute lymphoblastic leukaemia (ALL).
Some 1,400 people die of ALL in the United States each year, and while it is among the most treatable cancers, patients often become resistant to chemotherapy and eventually relapse.
For this study, 14 of 16 adult patients achieved complete remission after their T cells were genetically engineered so that they could focus on eradicating cancer.
The patients’ median age was 50, and they were all on the brink of death when they entered the trial, having relapsed or discovered that chemotherapy was no longer working.
The longest remission among them so far is about two years, and that patient is still going strong, said lead author Renier Brentjens, director of cellular therapeutics at Memorial Sloan Kettering Cancer Center.
Without this therapy, just 30 percent of relapsed patients would be expected to respond to salvage chemotherapy.
‘Re-educating’ T cells
The process involves removing some of the patient’s T-cells and altering them with a gene to make them recognize a protein, known as CD19, on the cancer cells, so that they can attack them.
Left to their own devices, T cells can attack other harmful invaders in the body but will allow cancer to grow uninterrupted.
“Basically, what we do is re-educate the T cell in the laboratory with gene therapy to recognize and now kill tumor cells,” Brentjens said.
After 15 years of work on the technology, known as tumor-targeted chimeric antigen receptor-modified T cells, “it seems to really work in patients with this particular type of cancer,” Brentjens told AFP.
Last year, his team reported the first promising results in five adult patients who achieved remission after the therapy.
He estimated that between 60 and 80 people in the United States have since entered experimental trials of the new treatment, which is also being studied in Europe.
‘Not a fluke’
In December 2013, experts from multiple US centers where trials are ongoing presented their findings at the American Society of Hematology (ASH) annual meeting, including the University of Pennsylvania, which is also studying the approach in adults with chronic lymphocytic leukaemia (CLL).
The Children’s Hospital of Philadelphia is enrolling pediatric patients in trials of T-cell therapy.
Brentjens said other US centers have shown similar remission rates in their studies so far, “demonstrating that this isn’t a fluke.”
This is a real phenomenon. This could be a paradigm shift in the way we approach cancer therapy.
Researchers are still trying to figure out why it does not work in all patients.
Efforts are also ongoing to identify cancer-specific receptor cells that could allow the technique to tackle other types of tumors.
“The expansion to other kinds of cancers is next on the to-do list,” said Brentjens.
In the meantime, the therapy remains expensive, costing around $100,000 per patient, a price tag experts believe will come down once pharmaceutical companies get more involved and the technique becomes more widespread.
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To be honest it beats the alternative – having fake brands which really take you out of the film. Nothing worse than a movie character cracking open a can just labelled “beer”
Ya, the movie world is filled with mind reading barmen aswell. I’d love to be able to walk into a bar and order a “Beer” and get what I want every time!
Go to some restaurants in Italy and that’s what happens. A two page list of wine with two beers at the bottom called small and large.
The product placements in Wayne’s World were satirical and totally over the top for the sake of comedy, this example doesn’t really fit in with the rest!
If this article is giving you a headache, Rob Hunt, you should take two Nuprin.
Ah, Nuprin. Little. Yellow. Different.
Or you could try JIMPRIN, a generic version that may be even better!
JIMPRIN! Almost made in Ireland!!
James Bond Skyfall with Heinekin and the Sony laptops.
I think the icing on the skyfall sell out cake was…
M:What was that?
Moneypenny: Volkswagen beetles I believe ma’m
I thought for a second she was going to add ‘what I can’t believe is they start from only €16K’
In fairness Bond has a noble heritage of schlepping. In Goldfinger You could have a drinking game out of the amount of times Sean Connery during his golf march wit Aurich Goldfinger says the word Slazenger.
I Lol’d at that
I hate product placement just about as much as I love a nice ice filled glass of Bulmers on a sunny day…
The movie producers and companies are out to make money, yet I think this speaks more to human beings and their desire to want something that they see in a movie, regardless of how useless that thing may be.
Have you seen the Product Placement in Fair City :) woaaaaa
Too true they’re shameless!
Some other company were offered the placement in ‘Castaway’, wouldn’t take it because they thought the plane crash would be bad for business.
The guy who filmed castaway was a former marine who served his time in Vietnam with the CEO of FEDEX.
At the time the board did not want the company to go ahead and feature in the movie but the CEO managed to push it through, , From memory it is the only actual airline ever to have a plane crash.
There’s a fascinating development in product placement. A company called Morris’s have developed technology which allows post production placement.
Essentially this means that anything which as ever been filmed wether yesterday or 50 years ago, can have products placed in it.
They have a showreel which includes a Kellogg’s cereal on the breakfast table of a Cosby show episode which predates the product by about five years.
http://www.mirriad.com/tag/digital-product-placement/
This means placement can be sold in different territories for different products.
There was a recent episode of how I met your mother which featured one of the characters carrying a shopping bag. The space on the bag was sold multiple times (down to zip code level) by individual broadcasters & where it wasn’t sold. It was blank with no disruption to the scene.
The Truman show. A very very very large product ad
What a moany article.
Are you seriously suggesting there should be no name brand products in films? Yeah, that’ll make it more natural.
There was nothing unnatural about any of these products. Imagine, a named car in a film about… Cars?!
Sharon’s stones ” Toothless Grin” in basic instinct
Remember a blatant one for Nike, in Heath Ledger’s ‘A Knights Tale’. Crap film anyway but that plug was shameless.
Nike not capitalizing… While they did only release 1500 (not 1000 fact check anyone?) pairs they also sold them in a bidding process for $3,500-10,000 a piece.
That’s a BMW Z8 from The World Is Not Enough pictured, not the Z3 from Goldeneye.
I am sick to death of the Apple’s product placement. iphone & MACs everywhere. And if the ‘baddie’ in the tv seriesbor movie takes out his phone, it looks like a blackberry.
The most blatant were Cheerios back in the late 70s, the cereal boxes were framed and lit better than the actors
I’m surprised the movie jack and jill with Adam Sandler was left out of this list…. Worst product placements I’ve ever seen. The ones above aren’t too bad… The whole movie was based on trying to get a Dunkin Donuts commercial made.
Because the film was so bad that no one saw it and the placements.
I’m glad no one has seen it. Horrible money grabbing piece of crap.
The picture of Bond was in Azerbaijan in The World is not Enough standing next to the BMW z8 the z3 roadster was in Goldeneye :)
Don’t forget Mac & Me, an entire movie made to promote MacDonalds
don’t get this article?? product placement is all the rage these days to even in lot of tv shows as well, and animated programmes like southpark
Mission impossible in Dubai. BMWs new 1 and 3 series and X5 used alot! Also in up in the air, American Airlines an Hilton are heavily used and advertised but I heard this was for the free use of the hotels and planes
Surely men in black for ray ban has to be there.
The movie Mac & Me should definitely be on that list. It’s an ET rip-off where the alien character spends his time consuming MacDonalds, Skittles and Coca Cola. It even has a 5 minute dance scene in MacDonalds in which Ronald MacDonald joins in on the fun.
Don’t. Forget the subtle method of thejournal.ie to include newstories which are actually adverts…. how dare they provide a free service and try to recoup costs through advertising … don’t forget talkshows like opera and the late late show. I’m also lead to believe that the rte news is sponsored by the sitting government. :)
They’ve nothing on Microsoft, I mean Hawaii, Five O though.
The Miller truck I bad boy’s 2 was so bad just a long dramatic sweeping camera shot of the Miller truck pass in slow motion
In the movie Anger Management, a movie set in NYC that was released shortly after 9/11, you can see several ads for U.S army recruitment.
What about Heineken in skyfall?
Product Placement has been around for years and always will be.
Watched ‘In The Heat Of The Night’ last night and Coca Cola featured prominently, didn’t ruin my enjoyment of the film though and the funding helps get the films made.
Smoking though does bother me, shameless placement in scenes you don’t see anymore, such as people smoking in offices and bars etc and really should be stamped out.
It is easy enough to get any product placement for the goodies in white hats…….try getting some for the the guys in the black hats, sadly the baddies are not really what the advertisers seem to want .
Oh dingleberrycity.com would never bother with product placement.
Transformers, General Motors, Xbox, Nokia, EBay, Burger King amongst others, and numerous references to Michael Bays other films….
Burger King in first Iron Man
The BMW z3 wasn’t in Goldeneye, it was in The World is Not Enough :)
What about Paddy Whiskey in On TheWaterfront?
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