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File photo of man checking blood sugar by glucometer. Alamy Stock Photo

Losing weight can put type 2 diabetes in remission ‘for at least five years’, UK study says

The data suggests that losing weight and keeping it off can help reverse diabetes.

LOSING WEIGHT CAN put type 2 diabetes in remission for at least five years, new data suggests.

Figures from the Diabetes Remission Clinical Trial (DiRECT) show that around a quarter of people in remission from diabetes two years after starting a low-calorie diet were still in remission three years later.

These people no longer needed to take medication to manage their blood sugar levels and had an average weight loss of around 1st 6lb (8.9kg) at the five-year point.

The data suggests that losing weight and keeping it off can help reverse diabetes, a serious condition which increases the risk of heart disease, stroke, high blood pressure, narrowing of blood vessels and nerve damage.

Obesity is a major driver of type 2 diabetes, with research suggesting that obese people are up to 80 times more likely to develop the condition than those with a healthy body mass index (BMI) of less than 22.

Of the 298 people who took part in the original DiRECT study, half received standard diabetes care from their GP and half were put on a diet with support from health professionals.

This included a low-calorie, nutrient-complete soup and shake diet (around 800 calories per day) for between 12 and 20 weeks, together with support from a nurse or dietician to reintroduce healthy foods and maintain weight loss.

Medications for type 2 diabetes and blood pressure were stopped at the beginning of the programme and reintroduced as necessary.

At the end of the original two-year study, 95 of the 149 people on the weight-loss programme agreed to take part in an extension study lasting three years.

This new data shows that, of this group of 95 people, 48 were in remission at the start of the extension study, and 23% of these were still in remission three years later.

 

The proportion of people in remission five years after the original study started was more than three times that of the DiRECT control group, who just received usual GP care.

Remission was closely linked to weight loss and keeping the pounds off. Researchers said those people who came out of remission had regained the weight they had lost.

Anyone who regained more than just over 4lb (2kg) during years three to five of the study were offered an additional package of support, available once a year, consisting of the low-calorie soups and shake diet for four weeks, followed by help while reintroducing normal meals.

Compared to the control group, those put on a diet and offered support had bigger improvements in blood pressure and blood sugar levels and fewer people needed medication.

The number of serious health issues resulting in hospital admission in the dieting group was also less than half that in the control group.

 

Diabetes UK, which funded the study, said the findings support growing evidence that weight loss and remission from type 2 diabetes can prevent or delay the complications of diabetes.

Professor Mike Lean, at the University of Glasgow, who co-led the study, said: “Type 2 diabetes causes a range of progressive and life-shortening complications, notably blindness, infections, amputations, kidney failure and heart failure.

“It affects over four million people in UK and accounts for about 10% of NHS funding.

“The DiRECT extension (study) has shown us that a substantial proportion of people, managed in primary care, can maintain sufficient weight loss to be free from the condition for up to five years.”

Professor Roy Taylor at Newcastle University, who also led the study, said: “The DiRECT five-year follow-up shows that the rapid weight-loss programme brings about considerable weight loss at five years with low-intensity support.

“The most important question now is how the follow-up programme can be even more successful at an affordable cost.”

 

Dr Elizabeth Robertson, director of research at Diabetes UK, said: “The new findings from DiRECT confirm that for some people, it is possible to stay in remission for at least five years.

“For those who put type 2 diabetes into remission, it can be life-changing, offering a better chance of a healthier future.

“For those that aren’t able to go into remission, losing weight can still lead to major health benefits, including improved blood sugar levels, and reduced risk of serious diabetes complications such as heart attack and stroke.”

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    Mute Fi Wyse
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    Apr 19th 2023, 8:59 AM

    800 calories a day is way too low. That’s verging on starvation, you would need to have at least 1400 calories a day to have any type of energy to do quality weightlifting which is something that would absolutely be needed to stop your body from losing too much muscle with such a drastic calorie cut.
    Losing weight too quickly is not healthy!

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    Mute Em
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    Apr 19th 2023, 12:31 PM

    I am 38 with a BMI of 21, eat relatively clean and don’t eat a lot of sweets, don’t take sugar in tea or coffee or take sugary cereals or drinks . I have recently been given blood test results and the gp suggested that that I’m pre diabetic based on fasting blood glucose. I was given the results by phone so I don’t think the doctor had information on my weight etc I got told “stop eating sugar” at a complete loss I started cutting out anything with sugar in it (potatoes, bread etc) and weight fell off me. I’ve reverted back to normal eating and cut out white bread but it would appear type 2 diabetes isn’t always linked to diet and weight. Would love more information on how to reduce risk in this area other than lose weight. That’s the information that seems to be the hardest to find.

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    Mute Marian O Donnell
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    Apr 19th 2023, 9:51 PM

    @Em: Totally Agree with you I only weigh 8 Stone

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    Mute Gavin Gray
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    Apr 19th 2023, 11:25 AM

    Well I’m not doctor, but I think that losing weight is an obvious way to avoid diabetes

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    Mute Madra
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    Apr 19th 2023, 8:47 AM

    Anywhere in Ireland able to help with this?

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    Mute Yvon Queguiner
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    Apr 19th 2023, 8:55 AM

    @Madra: You need help to eat properly and do a little bit of exercise?
    Plenty of resources on the NHS website, your GP, nutritionist, gyms.
    Most people only lack the will to do it.

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    Mute Yvon Queguiner
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    Apr 19th 2023, 10:53 AM

    @Véronique Durand: The Bel end can’t read apparently. Didn’t you see the list of resources? NHS, HSE, Gyms, GP, nutritionists.
    But you don’t seems to understand basic sentences.

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    Mute Marian O Donnell
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    Apr 19th 2023, 9:49 PM

    I Don’t Understand when they say you have to lose Weight to get Diabetis 2 under Control I was Diagnosed with Type 2 Diabetis 2 during the Pamdemic I got a Phone call saying I’d have to loose Weight I Literally can’t Afford to lose Weight I only weigh 8 Stone so still puzzling

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