RETAIL GIANT WALMART has become the latest major player in the drug industry to announce a plan to settle lawsuits filed by state and local governments over the toll of powerful prescription opioids sold at its pharmacies across the US.

The $3.1 billion (€3 billion) proposal follows similar announcements earlier in November from the two largest US pharmacy chains, CVS Health and Walgreen Co, which each said they would pay about $5 billion (€4.8 billion).

Arkansas-based Walmart said in a statement that it “strongly disputes” allegations in lawsuits from state and local governments that its pharmacies improperly filled prescriptions for the powerful prescription painkillers. The company does not admit liability with the settlement plan.

New York Attorney General Letitia James said in a release that the company would have to comply with oversight measures, prevent fraudulent prescriptions and flag suspicious ones.

Lawyers representing local governments said the company would pay most of the settlement over the next year if it is finalised.

The deals are the product of negotiations with a group of state attorneys general, but they are not final.

The CVS and Walgreens deals would have to be accepted first by a critical mass of state and local governments before they are completed. Walmart’s plan would have to be approved by 43 states. The formal process has not yet begun.

The national pharmacies join some of the biggest drugmakers and drug distributors in settling complex lawsuits over their alleged roles in an opioid overdose epidemic that has been linked to more than 500,000 deaths in the US over the past two decades.

The tally of proposed and finalised settlements in recent years is more than $50 billion (€48.2 billion), with most of that to be used by governments to combat the crisis.

In the 2000s, most fatal opioid overdoses involved prescription drugs such as OxyContin and generic oxycodone. After governments, doctors and companies took steps to make them harder to obtain, people addicted to the drugs increasingly turned to heroin, which proved more deadly.

In recent years, opioid deaths have soared to record levels around 80,000 a year. Most of those deaths involve illicitly produced version of the powerful lab-made drug fentanyl, which is appearing throughout the US supply of illegal drugs.